Cisplatin for triple negative breast cancer
WebJan 25, 2010 · Cisplatin is a chemotherapeutic agent not used routinely for breast cancer treatment. As a DNA cross-linking agent, cisplatin may be effective treatment for hereditary BRCA1 -mutated breast cancers. WebJun 6, 2007 · Cisplatin and carboplatin are anti-cancer chemotherapy drugs that stop cancer cells from growing abnormally and is used to treat other cancers. Evaluate a new biomarker to help determine which breast cancers are most likely to …
Cisplatin for triple negative breast cancer
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WebApr 8, 2024 · Breast cancer is classified into three key subtypes based on hormone receptor (HR) and human epidermal growth factor 2 (HER2) status: HR+/HER2−, HER2+, and triple-negative breast cancer (TNBC). Therapeutic selection in breast cancer has … WebNational Center for Biotechnology Information
WebApr 1, 2024 · Triple-negative tumor cells, a malignant subtype of breast cancer, lack a biologically targeted therapy. Given its DNA repair inhibiting properties, caffeine has been shown to enhance the effectiveness of specific tumor chemotherapies. In this work, we have investigated the effects of caffeine, cisplatin, and a combination of the two as potential … WebJul 15, 2024 · Abstract Resistance to chemotherapy continues to be a critical issue in the clinical therapy of triple-negative breast cancer (TNBC). Epithelial-mesenchymal transition (EMT) is thought to contribute to chemoresistance in several …
WebA triple combination gemcitabine + romidepsin + cisplatin to effectively control triple-negative breast cancer tumor development, recurrence, and metastasis Cancer Chemother Pharmacol. 2024 May 27. doi: 10.1007/s00280-021-04298-y. … WebFeb 25, 2024 · The Triple Negative Breast Cancer Trial (TNT) randomly assigned patients with metastatic TNBC to either docetaxel or carboplatin in the first-line treatment setting. 4 Results showed that carboplatin was …
WebApr 8, 2024 · Stage 4 triple-negative breast cancer/triple-negative breast cancer metastasis: The initial treatment for patients with this type of cancer is usually chemotherapy. For those with triple-negative disease and a BRCA mutation, platinum-based therapies such as carboplatin or cisplatin may be used.
WebJun 22, 2024 · Cisplatin (DDP) was reported to improve pathological complete response (pCR) rates in triple-negative breast cancer (TNBC) patients, however, the molecular mechanism still remains largely unknown. Emerging evidence suggested that some chemotherapeutic drugs played anti-tumor effects by inducing cell pyroptosis. pink panther street artWebJan 4, 2024 · Triple-negative breast cancers (TNBCs) have shown sensitivity to decitabine; however, the underlying mechanism of its anticancer effect and its effectiveness in treating TNBCs are not fully understood. We analyzed the effects of decitabine on nine TNBC cell lines and examined genes associated with its cytotoxic effects. steel wire coil suppliersWebKnockdown, chromatin immunoprecipitation, and reporter assays all showed that p63 regulates MFG-E8 expression, and MFG-E8 knockdowns sensitized triple-negative breast cancers to cisplatin treatment. Taken together, our results show that MFG-E8 is expressed in triple-negative breast cancers as a target gene of the p63 pathway, but may serve a ... steel will plague doctor knifeWebApr 3, 2024 · The chemotherapy reduces the risk of the breast cancer coming back. You usually have a combination of chemotherapy drugs that might include: doxorubicin epirubicin paclitaxel docetaxel carboplatin cisplatin Researchers are still looking into the best chemotherapy combinations. pink panthers robbersWebAug 29, 2012 · This is a Phase I dose escalation study of cisplatin and concurrent radiation in patients with ER negative, PR negative and HER2 negative breast cancer who have … steel wire fencing contractors north westWebMany drugs used to treat breast cancer, including taxanes (docetaxel, paclitaxel, and protein-bound paclitaxel), platinum agents (carboplatin, cisplatin), vinorelbine, eribulin, and ixabepilone, can damage nerves in the hands, arms, feet, and legs. pink panther strikes again archiveWebKnockdown, chromatin immunoprecipitation, and reporter assays all showed that p63 regulates MFG-E8 expression, and MFG-E8 knockdowns sensitized triple-negative … steel wire cold heading