Ctcf-binding
WebCCCTC-binding factor (CTCF) is a versatile transcription regulator that is evolutionarily conserved from fruit fly to human. CTCF binds to different DNA sequences through combinatorial use of 11-zinc fingers, and shows distinct functions (transcription activation/repression and chromatin insulation) depending on the biological context. WebJan 14, 2024 · The DNA-binding protein CCCTC-binding factor (CTCF) and the cohesin complex function together to establish chromatin loops and regulate gene expression in mammalian cells. It has been proposed that the cohesin complex moving bidirectionally along DNA extrudes the chromatin fiber and generates chromatin loops when it pauses …
Ctcf-binding
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WebMar 11, 2014 · CCCTC-binding factor (CTCF) is a DNA-binding protein that has various, often seemingly contradictory, roles in gene regulation. This Review describes these … WebNov 2, 2007 · INTRODUCTION. CCCTC-binding factor (CTCF) is a versatile transcription regulator that is evolutionarily conserved from fruit fly to human ().CTCF binds to different …
WebCTCF is an architectural protein with a critical role in connecting higher-order chromatin folding in pluripotent stem cells. Recent reports have suggested that CTCF binding is more dynamic during development than previously appreciated. WebSep 15, 2024 · Gained/lost CTCF binding events associate with chromatin dynamics. a, c, e, g Volcano plots showing differential chromatin interaction levels between cancer and …
WebPurpose: A previous study demonstrated that CTCF (CCCTC binding factor) regulates homeobox Pax6 gene expression in early embryonic stages and plays a dominant role in … WebMar 21, 2024 · CTCF binding modulates UV damage formation to promote mutation hot spots in melanoma. Structure-function relationships explain CTCF zinc finger mutation phenotypes in cancer. QPCT regulation by CTCF leads to sunitinib resistance in renal cell carcinoma by promoting angiogenesis.
WebCTCF (the CCCTC-binding factor) is a sequence-specific DNA binding protein that recognizes extended DNA motifs with its 11 zinc fingers and acts as a critical regulator of interphase genome folding (Splinter et al. 2006), which underlies the formation of physical contacts among distant cis-regulatory elements, thus contributing to selectivity ...
WebWe observed subset-specific changes in chromatin organization and CTCF binding and revealed that weak-affinity CTCF binding promotes terminal differentiation of CD8 + T cells through the regulation of transcriptional programs. Further, patients with de novo CTCF mutations had reduced expression of the terminal-effector genes in peripheral blood ... friendly house pdxWebGenomic coordinates of CTCF binding sites, with strand orientation (directionality of binding). Position weight matrices (PWMs) from JASPAR, HOCOMOCO, CIS-BP, … friendly house portland oregonWebCTCF Binding Sites by ChIP-seq from ENCODE/University of Washington Track collection: ENCODE Transcription Factor Binding . Description: Transcription is regulated through … friendly house portland orWebAug 23, 2024 · Because CTCF binding to genomic DNA is important for the maintenance of genomic integrity and CTCF is an RNA-binding protein (28–31), we performed RNA immunoprecipitation (RIP) analysis, demonstrating that the ZF DNA- and RNA-binding domains of CTCF are important for their binding to not only an exogenous hSATII RNA … friendly house phoenix azWebJun 19, 2013 · CTCF-binding sites interact to create a chromatin hub with a loop encompassing the LCR and the β-globin genes. Upon erythroid differentiation, erythroid … friendly house turlockWebDec 23, 2008 · To distinguish CTCF recruitment specifically to endogenous or ectopic HS5, we used nested PCR to uniquely amplify a fragment from each HS5 copy and then amplify the CTCF site therein (Fig. 1B). CTCF interacted at ectopic HS5 but was absent when the CTCF motif was deleted, while binding to the endogenous HS5 site was retained in both … friendly house roodepoortWebAug 26, 2015 · The orientation of CCCTC-binding factor (CTCF)-binding sites located in enhancers and promoters dictates the directionality of CTCF binding and thus chromatin … fawning press definition