WebJan 15, 2016 · Daratumumab Interference in Pre-Transfusion Testing. Aleh (Oleg) Bobr M.D. Affiliation: University of Nebraska Medical Center. ... Vooght, "When blood transfusion medicine becomes complicated due to interference by monoclonal antibody therapy," Transfusion, vol. 55, pp. 1555- 1562, 2015 8. Liu J, Santhanakrishnan M, … WebDaratumumab interacts with red blood cells, interfering with pre-transfusion testing. This interference can lead to compromising transfusion safety, extensive blood bank work …
Daratumumab - Wikipedia
WebIntravenous daratumumab (DARZALEX ®) is a human CD38 monoclonal antibody approved as combination therapy (with bortezomib, melphalan and prednisone) for … WebIntroduction. Autoimmune hemolytic anemia (AIHA) is due to increased destruction of red blood cells (RBC) mainly driven by autoantibodies and complement (C), but also to other immune players (activated macrophages, T-lymphocytes, and cytokines). 1 The disease is highly heterogeneous, from mild/compensated to life-threatening forms. The major … software delivery tools
PEARLS OF LABORATORY MEDICINE - AACC
WebFeb 22, 2024 · On November 16, 2015, the U.S. Food and Drug Administration (FDA) approved the first monoclonal antibody, daratumumab or DARA (anti-CD38), for the treatment of patients with multiple myeloma. 5 Since then, several trials have been performed to extend the application of this new drug, or to develop other monoclonal … WebDec 28, 2024 · Chari A, Arinsburg S, Jagannath S, et al. Blood transfusion management and transfusion-related outcomes in daratumumab-treated patients with relapsed or refractory multiple myeloma. Clin Lymphoma Myeloma Leuk. 2024;18(1):44-51. WebSep 14, 2016 · Daratumumab (DARA), an immunoglobulin that targets CD38 on myeloma cells, was recently approved by the U.S. FDA. DARA, however, also binds to CD38 on red blood cells (RBCs), which interferes with blood compatibility testing if the patient also needs a blood product. software delsol