WebNov 26, 2024 · Taken together, our data demonstrate that targeting WEE1 up-regulates ERVs, IFN activation, and PD-L1 in tumors. This response may be critical in cGAS/STING-deficient cancer cells representing a common phenotype across multiple cancer lineages. The ability of WEE1i to induce ERV expression is due to interrupting H3K9Me3 … WebDec 1, 2024 · In summary, our data in cancer cell lines, tumor-bearing mouse models, and patients with melanoma demonstrate that pharmacologic p53 reactivation triggers the ERV–dsRNA–IFN pathway within tumor cells thereby altering the tumor microenvironment toward a therapeutically responsive phenotype and evoking tumor immune surveillance.
Frontiers HERVs New Role in Cancer: From Accused …
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SETDB1 Restrains Endogenous Retrovirus Expression …
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