Rifm report on linalool
Web9 Member RIFM Expert Panel, Vanderbilt University School of Medicine, Department of Biochemistry, Center in Molecular Toxicology, ... The developmental and reproductive toxicity endpoint was completed using linalool (CAS # 78-70-6), dehydrolinalool (CAS # 29171-20-8), benzoic acid (CAS # 65-85-0) and sodium benzoate (CAS # 532-32-1) as … WebJul 1, 2003 · The principal toxic effects observed were hypermotility with ataxia followed by sedation or depression and dyspnea ( RIFM, 1992 ). The i.p. LD 50 in male albino mice of a solution of linalool in isotonic sodium chloride with Tween 80 added was reported to be 0.340 g/kg (95% C.I. 0.267–0.510 g/kg). Animals were dosed at levels of 0.075–0.8 g/kg.
Rifm report on linalool
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WebThe developmental and reproductive toxicity endpoint was completed using linalool (CAS # 78-70-6), dehydrolinalool (CAS # 29171-20-8), benzoic acid (CAS # 65-85-0) and sodium benzoate (CAS # 532-32-1) as suitable read across analogs, which provided a MOE > 100. WebMar 1, 2008 · In a 90-day dermal study, linalool was applied topically to Sprague-Dawley rats at doses of 250, 1000, or 4000 mg/kg/day. Dermal erythema was noted at all dose levels. At 250 mg/kg/day, there were no systemic changes observed ( Letizia et al. 2003; RIFM 1980 ).
WebThe developmental toxicity endpoint was completed using linalool (CAS # 78-70-6), dehydrolinalool (CAS # 29171-20-8) and cinnamic acid (CAS # 621-82-9) as suitable read across analogs, which provided a MOE > 100. The repeated dose toxicity endpoint was completed using data on the target material which provided a MOE > 100. WebRIFM evaluates all existing data and real-world consumer exposure to determine conditions of safe use for consumers, focusing on genotoxicity, repeated dose and reproductive …
WebApi, A. M., Belsito, D., Bhatia, S., Bruze, M., Calow, P., Dagli, M. L., … Wilcox, D. K. (2015). RIFM fragrance ingredient safety assessment, Linalool, CAS registry ... WebNov 1, 2024 · Request PDF On Nov 1, 2024, A.M. Api and others published RIFM fragrance ingredient safety assessment, linalool, CAS Registry number 78-70-6 Find, read and cite all the research you need on ...
WebNov 1, 2016 · l-Linalool safety assessment based on RIFM's criteria. • Safety assessment based on 7 Human health endpoints plus environmental. • Repeated dose toxicity was determined to have the most conservative NO [A]EL. • An acceptable MOE was obtained. Abstract The use of this material under current use conditions is supported by the existing …
WebJan 28, 2015 · The use of linalool as an ingredient, according to the OECD report (CAS Number 78-70-6 2002), suggested that the compound has an LD50 following a cutaneous administration of 2000 mg/kg of body ... community health resources manchesterWebNov 1, 2008 · Search life-sciences literature (Over 39 million articles, preprints and more) community health resources putnam ctWeblinalool L. 2 515-69-5 Cabreuva oil Myrocarpus frondosus Fr. Allem 68188-03-4 D2.12 0.3 515-69-5 ... • The RIFM Safety Assessment on α-Bisabolol if available at the RIFM Safety Assessment Sheet ... • IDEA project (International Dialogue for the Evaluation of Allergens) Final Report on the QRA2: Skin Sensitisation Quantitative Risk ... community health resource center cpmcWebJan 28, 2015 · Linalool (C10H18O) is a monoterpenoid found in plant essential oils. It has a molecular weight of 154.25 and has properties that are less soluble in water because of … community health resources jobsWebb. Repeated Dose Toxicity: Linalool(CAS#78-70-6) c. Developmental and Reproductive Toxicity: Linalool(CAS# 78-70-6);dehydrolinalool(CAS#29171-20-8) d. Skin Sensitization: … community health resources norwichWebMar 1, 2008 · A no observed effect level (NOEL) of 160 mg/kg/day (equivalent to 117 mg/kg linalool) for males and less than 160 mg/kg/day for females was determined (Letizia et al. … community health resources bloomfield ctWebJan 28, 2015 · RIFM fragrance ingredient safety assessment, Linalool, CAS registry number 78-70-6. ... Linalool, CAS registry number 78-70-6. Api AM 1, Belsito D 2, Bhatia S 1, Bruze M 3, Calow P 4, Dagli ML 5, Dekant W 6, Fryer AD 7, Kromidas L 1, La Cava S 1, Lalko JF 1, Lapczynski A 1, ... easyshiksha.com